1. In general, we use a multidisciplinary approach that combines genetically manipulated mice, pharmacological, molecular and cell biology studies, and electrophysiological and behavioral studies in alert behaving mice. Some of these techniques are also available for behaving rats.
  2. Classical eyeblink conditioning, instrumental learning with different paradigms and experimental designs
  3. Activity-dependent synaptic changes in strength and long-term potentiation (LTP) and depression (LTD) studies in alert behaving mammals. In vivo recording techniques (unitary and field potentials) of brain electrical activity.
  4. Brain-machine interactions and stimulation and recording procedures
  5. These experimental models are susceptible to be used for pharmacological screening and for memory and learning capabilities of genetically-manipulated mice and rats. Micro-injection, micro-dialysis and micro-stimulation techniques are also available.
  6. Other behavioral techniques: We have established a battery of behavioral tasks to evaluate basic mouse behavior and, more precisely, to assess explicit forms of memory. This battery includes aversive avoidance, spatial learning at the Barnes maze, object recognition, etc. Also, we have experience in different test of acute and chronic pain.
  7. Software for analysis and representation using a wavelet analysis program is also available.
  8. Mathematical modeling of classically and instrumentally conditioned behaviors. Multivariate and causal analysis of brain activities during learning